BCL-2 family

Scientific explanation

BCL-2, BCL-XL, MCL-1 and BAX/BAK control outer-membrane permeabilization, a core checkpoint frequently skewed toward survival in lymphoid and solid tumours.

Cancers where relevant

Small-cell lung cancer Neuroendocrine prostate cancer Leukemias Acute myeloid leukemia Acute lymphoblastic leukemia Non-Hodgkin lymphoma Multiple myeloma Neuroendocrine tumors

Compounds that intersect this pathway

This oncology atlas is educational. Pathway maps, adjunctive strategies, and compound listings describe mechanistic relevance. They do not establish clinical efficacy, do not recommend treatment, and are not a substitute for oncology care. Evidence tiers are not equivalent.