Drug efflux

Scientific explanation

ABC transporters such as ABCB1/P-gp, ABCC1 and ABCG2 export structurally diverse drugs and contribute to multidrug-resistance phenotypes.

Cancers where relevant

Triple-negative breast cancer Ovarian cancer Castration-resistant prostate cancer

Compounds that intersect this pathway

Ivermectin

Glutamate-gated chloride channel in invertebrates. Reported mammalian effects on nuclear transport and signalling pathways come from experimental systems and do not constitute proven anticancer therapy.

This oncology atlas is educational. Pathway maps, adjunctive strategies, and compound listings describe mechanistic relevance. They do not establish clinical efficacy, do not recommend treatment, and are not a substitute for oncology care. Evidence tiers are not equivalent.