EMT

Scientific explanation

Epithelial–mesenchymal plasticity, driven by TWIST/SNAIL/ZEB and TGF-β/Wnt/Notch inputs, reduces adhesion and increases motility and stem-like features.

Cancers where relevant

Breast cancer Triple-negative breast cancer Lung cancer Non-small-cell lung cancer EGFR-mutant NSCLC MET-altered NSCLC Colorectal cancer MSS colorectal cancer Pancreatic cancer Gastric cancer Esophageal cancer Cholangiocarcinoma Ovarian cancer Cervical cancer Prostate cancer Bladder cancer Glioblastoma Melanoma Head and neck cancers Sarcomas Bone cancers

Compounds that intersect this pathway

This oncology atlas is educational. Pathway maps, adjunctive strategies, and compound listings describe mechanistic relevance. They do not establish clinical efficacy, do not recommend treatment, and are not a substitute for oncology care. Evidence tiers are not equivalent.