Oncology pathway explorer
Ferroptosis
Scientific explanation
is iron-dependent lipid-peroxidation cell death opposed by GPX4 and cystine/GSH supply. Some therapy-resistant and mesenchymal states show altered sensitivity.
Cancers where relevant
Compounds that intersect this pathway
Cysteine donor replenishing glutathione. Redox buffering can be protective or, in some models, support tumour antioxidant capacity. Dual-edged; not an antineoplastic.
Evidence in mapped cancers: In Vitro · Mechanistically Plausible · Hypothesis-Generating
Convergence partners
Other pathways that co-occur with Ferroptosis on mapped adjunct records: Oxidative stress, NRF2.
This oncology atlas is educational. Pathway maps, adjunctive strategies, and compound listings describe mechanistic relevance. They do not establish clinical efficacy, do not recommend treatment, and are not a substitute for oncology care. Evidence tiers are not equivalent.