Invasion

Scientific explanation

Invasion requires adhesion turnover, cytoskeletal protrusion and protease-mediated matrix remodelling (MMPs, uPA).

Cancers where relevant

Compounds that intersect this pathway

Doxycycline

Tetracycline antibiotic that can inhibit matrix metalloproteinases and, at experimental exposures, protein synthesis. Oncology uses remain investigational.

Evidence in mapped cancers: In Vitro · In Vivo · Mechanistically Plausible

Propranolol

Non-selective β-adrenergic . Adrenergic signalling can support and invasion in some tumours; selected clinical experiences (e.g. infantile haemangioma is established vascular biology, oncology uses are a different question).

Evidence in mapped cancers: Early Clinical · In Vivo · In Vitro

Losartan

AT1- . In desmoplastic models, angiotensin blockade can reduce TGF-β-linked stromal compression and improve perfusion; this is adjunctive stromal biology, not cytotoxic oncology.

Convergence partners

Other pathways that co-occur with Invasion on mapped adjunct records: Angiogenesis, Cancer stemness, Mitochondrial oxidative phosphorylation.

This oncology atlas is educational. Pathway maps, adjunctive strategies, and compound listings describe mechanistic relevance. They do not establish clinical efficacy, do not recommend treatment, and are not a substitute for oncology care. Evidence tiers are not equivalent.