PARP / DNA repair

Scientific explanation

Homologous-recombination defects (BRCA1/2 and related) create dependence on PARP-mediated repair. Mismatch-repair deficiency creates hypermutation and immune visibility.

Cancers where relevant

Breast cancer Triple-negative breast cancer Small-cell lung cancer MSI-high colorectal cancer Ovarian cancer Prostate cancer Castration-resistant prostate cancer Leukemias Glioblastoma MGMT-methylated glioma

Compounds that intersect this pathway

This oncology atlas is educational. Pathway maps, adjunctive strategies, and compound listings describe mechanistic relevance. They do not establish clinical efficacy, do not recommend treatment, and are not a substitute for oncology care. Evidence tiers are not equivalent.